Metabolism fine-tunes macrophage activation
نویسندگان
چکیده
منابع مشابه
Metabolism Fine-tunes Macrophage Activation
C ells continually monitor the availability of nutrients and alter their activities and metabolism accordingly. Immune cells are no exception (O’Neill and Pearce, 2015). Macrophages are important immune cells that perform many roles – they are, for example, involved in development and wound repair – but they need to be activated before they can carry out their functions. For years it was though...
متن کاملMetabolism Supports Macrophage Activation
Macrophages are found in most tissues of the body, where they have tissue- and context-dependent roles in maintaining homeostasis as well as coordinating adaptive responses to various stresses. Their capacity for specialized functions is controlled by polarizing signals, which activate macrophages by upregulating transcriptional programs that encode distinct effector functions. An important con...
متن کاملFine-tuning nucleophosmin in macrophage differentiation and activation.
M-CSF-driven differentiation of peripheral blood monocytes is one of the sources of tissue macrophages. In humans and mice, the differentiation process involves the activation of caspases that cleave a limited number of proteins. One of these proteins is nucleophosmin (NPM1), a multifunctional and ubiquitous protein. Here, we show that caspases activated in monocytes exposed to M-CSF cleave NPM...
متن کاملTumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Tumor-associated macrophages (TAM) are exposed to multiple microenvironmental cues in tumors, which collaborate to endow these cells with protumoral activities. Hypoxia, caused by an imbalance in oxygen supply and demand because of a poorly organized vasculature, is often a prominent feature in solid tumors. However, to what extent tumor hypoxia regulates the TAM phenotype in vivo is unknown. H...
متن کاملThe role of PI3Kγ in metabolism and macrophage activation
The class 1 phosphoinositide 3-kinase (PI3K) is a family of enzymes which add a phosphate group in position 3 to the membrane lipid phosphatidylinositol4,5-bisphosphate to generate the second-messenger phosphatidylinositol-3,4,5-trisphosphate. The class-1 PI3K family is further subdivided into class-1A and class1B. Class-1A PI3Ks comprises PI3Kα; PI3Kβ; and PI3Kδ, which are typically recruited ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.14354